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The American Nurses Association (ANA) Professional Issues Panel, Barriers to RN Scope of Practice (SOP Panel), was established to identify and clarify barriers to registered nurses (RNs) practicing to the full extent of their education, experience, and scope of practice (SOP) as determined by the relevant nurse practice act. Key Words: advocacy, change, communication, coordination, critical thinking, delegation, education, financial skills, innovation, innovator, leader, National Quality Strategy, nurse, processes, policy, quality improvement, resiliency, simulation, technology, training, triple Aim This article describes a number of key innovation goals identified by the American Nurses Association Professional Issues Panel, Barriers to RN Scope of Practice, discusses relevant literature related to overcoming barriers to innovation, and identifies recommendations for leading innovative change to achieve innovation goals.Д¬itation: Thomas, T.W., Seifert, P.C., Joyner, J.C., (September 30, 2016) 'Registered Nurses Leading Innovative Changes' OJIN: The Online Journal of Issues in Nursing Vol. The authors consider examples of RNs leading innovative ideas and practices to create new knowledge develop healthcare policies and practices improve the quality of care and advance health information technology. As innovators, all registered nurses (RNs) act as agents of change to drive processes and policy and leverage technology to proveВ better, more affordable care for individuals and the community.